Natural around Santa Ana, Orange County, California to Dick & Donna Pfeiffer, she has triplet sib, an older brother and deuce immature sisters. She is of Dutch, German, Irish, Swedish and Swiss descent.

Around 1981, she married actor Peter Horton, but it late divorced. Around 1993, Pfeiffer adopted a girl, Claudia Rose Pfeiffer; in the future that season, she married producer David E. Kelley, the creator of the television series' Chicago Hope and Ally McBeal; a biological son was born in 1994 to Kelley and Pfeiffer.

Her foremost starring role was in the 1982 musical Grease 2, which could hardly presage her illustrious career by using fantastic performances within film like Married to the Mob, Batman Returns and What Lies Beneath, among others. Her virtually all recent operate includes roles in the flick Sinbad: Legend of the Seven Seas, What Lies Beneath, White Oleander, and I Am Sam.

As a singer, she became virtually all widely known using her role in The Fabulous Baker Boys.

Her immature sister Dedee Pfeiffer is also an actress, however mostly in TV.

Filmography
Falling in Love Again (1980) The Hollywood Knights (1980) Charlie Chan and the Curse of the Dragon Queen (1981) Grease 2 (1982) Scarface (1983) Into the Night (1985) Ladyhawke (1985) Sweet Liberty (1986) The Witches of Eastwick (1987) Amazon Women on the Moon (1987) Married to the Mob (1988) Tequila Sunrise (1988) Dangerous Liaisons (1988) The Fabulous Baker Boys (1989) The Russia House (1990) Frankie and Johnny (1991) Batman Returns (1992) Love Field (1992) The Age of Innocence (1993) Wolf (1994) Dangerous Minds (1995) Up Close & Personal (1996) To Gillian on Her 37th Birthday (1996) One Fine Day (1996) (also executive producer) A Thousand Acres (1997) (also producer) The Uttmost (1998) (documentary) The Prince of Egypt (1998) (voice) The Deep End of the Ocean (1999) ''A Midsummer Night's Dream (1999) The Story of Us (1999) What Lies Beneath (2000) I Am Sam (2001) White Oleander (2002) Sinbad: Legend of the Seven Seas (2003) (voice) Chasing Montana (2005) (currently inside pre-production)

TV work
The Solitary Man (1979) Delta House (1979) (canceled after Xv episodes) B.A.D. Cats (1980) (canceled after 6 episodes) Callie & Son (1981) Splendor in the Grass (1981) The Children Nobody Wanted (1981) One Too Many (1983) Tales from the Hollywood Hills: Natica Jackson'' (1987)